HPE Synergy 480 Gen11 Upgrade Guide
Maximize the performance and lifespan of your HPE Synergy 480 Gen11 (Gen11). Every upgrade option below is verified compatible.
Upgrade Storage
Moving from spinning disk to SSD or NVMe storage provides the largest single performance improvement — often 10-50x faster I/O. Consider NVMe for boot drives and high-IOPS workloads.

375696-001 HPE 36GB 10K SAS SFF SP HDD

375696-002 HP 72-GB 3G 10K 2.5 SP SAS HDD

375712-001 HPE 36GB 10K SAS SFF SP HDD

375859 HPE B21 375863 001 36GB 10K 3GB SAS SFF Hard Drive

375859-B21 HPE 36GB 10K SAS SFF SP HDD

375859R-B21 HP 36GB 10K SAS Hot Plug 2.5IN Hard Drive Disk (HDD)
Upgrade Controllers
Upgrading your RAID controller enables faster disk I/O, larger cache, and support for newer drive technologies. Essential when adding NVMe or SAS-4 drives.

001 HP 4M Netraid Adapter 128MB

158223-B21 HP 16-PORT Fibre Channel Switch

176804-002 HP 1-GB 64-BIT PCI Fibre Channel

250176-001 HP Fiber Channel Host

261329-B21 HP 2-GB 64-BIT PCI - FC

268351-B21 HP ULTRA320 SCSI Adapter
Upgrade Memory
Memory is the most impactful upgrade for virtualization and database workloads. Upgrading from 64GB to 128GB or 256GB can dramatically improve VM density and application response times.

590489-B21 HP CPU Memory Upgrade

P43322-B21 HPE 16GB 1Rx8 RDIMM DDR5-4800 PC5-38400R ECC Memory

P43322-K21 HPE 16GB RDIMM DDR5-4800 PC5-38400R ECC Memory

P43324-0A1 HPE 16GB RDIMM DDR5-4800 PC5-38400R ECC Memory

P43324-1A1 HPE 16GB RDIMM DDR5-4800 PC5-38400R ECC Memory

P43325-B21 HPE 32GB RDIMM DDR5-4800 PC5-38400R ECC Memory
Upgrade Processors
CPU upgrades deliver more cores and higher clock speeds. If your workload is CPU-bound (compilation, analytics, HPC), upgrading from 8-core to 16+ core processors provides significant throughput improvement.

001 HP 4M Netraid Adapter 128MB

120672-B21 Genuine HP

120673-B21 HP ProLiant Server Option Kit

123482-005 HP Fan Assembly

123958-001 HP ProLiant Server Component

144007-001 Genuine HP
Upgrade Chassis
This category provides verified compatible upgrade paths. ICD engineers validate every part for compatibility with your specific server model and workload requirements.

5064 HPE 6732 Elsa Gloria Synergy Agp Graphics

871599-B21 HPE HP OEM Synergy 480 GEN10 CTO Compute Module.

871929-B21 HP Synergy 660 GEN10 CONFIGURE-TO-ORDER Compute Module

871929-B22 HP Synergy 660 GEN10 TAA-COMPLIANT CONFIGURE-TO-ORDER Compute Module

871932-B21 HP Synergy 660 GEN10 8160 4P 256GB-R P408I-C SAS Performance Compute Module

871933-B21 HP Synergy 660 GEN10 6140 2P 128GB-R E208I-C Base Compute Module
Upgrade Power & Cooling
This category provides verified compatible upgrade paths. ICD engineers validate every part for compatibility with your specific server model and workload requirements.

391137-001 HP Heatsink for DL380 G5 DL385 G2

398293 HPE XW8400 XW6400 Heatsink Assembly

410749-001 HP DL360 G5 Heatsink

412210 HPE Heatsink for DL360 G5

469886 HPE Heatsink for Proliant DL385 G5P DL380 G6 496064 001

496064 HPE Heatsink DL380 G6 G7
Upgrade Networking
Stepping up from 1GbE to 10GbE or 25GbE eliminates network bottlenecks for VM migration, iSCSI storage traffic, and backup windows. Most modern workloads benefit from at least 10GbE.

384043R-B21 HP Dual NC370I Multifunction Network Adapter for Proliant BL25P/BL35P/BL45P (remarketed)

404986 HPE 403619 B21 QLogic QMH2462 4GB FC Mezzanine Board Lot of 4

507016R-B21 HP BLC7000 3PH 6PS Int Rohs iLO Advanced Pack (ice)

647579-001 HPE Broadcom 530FLR-SFP+ BCM57810S DUAL-PORT 10GBE Flexiblelom Adapter

691367 HPE B21 699350 001 Blc Vc Flexfabric 20 40 F8 Module

700764 HPE B21 701536 001 Flexfabric 20GB 2 Port 650FLB Fio Adapter
More HPE Synergy 480 Gen11 Resources
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