HPE ProLiant DL380p Gen8 Upgrade Guide
Maximize the performance and lifespan of your ProLiant DL380p Gen8 (Gen8). Every upgrade option below is verified compatible.
Next generation: ProLiant DL380 Gen9 (Gen9)
Verified Specifications
| Processor Options | Dual Intel Xeon E5-2600 / E5-2600 v2 series (up to 8 cores) |
| Memory Configuration | 24x DDR3 RDIMM slots - up to 768 GB at 1600 MHz |
| Drive Configurations | 8x or 25x 2.5in SFF - or 8x/12x 3.5in LFF hot-plug (Smart Array P420i) |
| Power Supply Options | HPE Common Slot hot-plug redundant options per QuickSpecs |
| Specification Source | HPE official documentation (verified 2026-07-02) |
Frequently Asked Questions
Upgrade Storage
Moving from spinning disk to SSD or NVMe storage provides the largest single performance improvement — often 10-50x faster I/O. Consider NVMe for boot drives and high-IOPS workloads.
07N8808 147-GB ULTRA320 SCSI HP 10K
07N8818 73.4-GB ULTRA320 SCSI HP 10K
07N9418 147-GB ULTRA320 SCSI HP 10K
07N9428 73.4-GB ULTRA320 SCSI HP 10K
08K0293 Hitachi 36-GB ULTRA320 SCSI HP 10K
08K0312 36-GB ULTRA320 SCSI HP 10K
Upgrade Memory
Memory is the most impactful upgrade for virtualization and database workloads. Upgrading from 64GB to 128GB or 256GB can dramatically improve VM density and application response times.
174225-B21 HPE 256MB RDIMM SDRAM-133 PC-133R ECC Memory
286763-B21 HP Modular Smart Array BL30P
310480-B21 HPE 512MB RDIMM DDR-266 PC-2100R ECC Memory
317093-B21 HPE 2GB RDIMM SDRAM-133 PC-133R ECC Memory
483401-B21 HPE 4GB RDIMM DDR2-667 PC2-5300R ECC Memory
483403-B21 HPE 8GB RDIMM DDR2-667 PC2-5300R ECC Memory
Upgrade Power & Cooling
This category provides verified compatible upgrade paths. ICD engineers validate every part for compatibility with your specific server model and workload requirements.
0974244 -03 HP 764W Power Supply 80 Plus 3PAR Storeserv
0HPX07 Dell Pe 495W Power Supply
105739-011 HPE 450W HOT-PLUG Redundant Power Supply for Proliant DL580 Gen1.
105739-021 HPE 450W HOT-PLUG Redundant Power Supply for Proliant DL580 Gen1.
105739-031 HPE 450W HOT-PLUG Redundant Power Supply for Proliant DL580 Gen1.
105739-291 HPE 450W HOT-PLUG Redundant Power Supply for Proliant DL580 Gen1.
Upgrade Networking
Stepping up from 1GbE to 10GbE or 25GbE eliminates network bottlenecks for VM migration, iSCSI storage traffic, and backup windows. Most modern workloads benefit from at least 10GbE.
118042-001 HP PCI10 100 NIC Card
127552-B21 HP 8-PORT Fiber Channel Switch
127553-B21 HP 16-PORT Fibre Channel Switch
138603-B21 HP NC3134 NIC 64 PCI Dual Port 10/100
161105-001 HP NC3134 Dual NIC Card
161106-001 HP NC3135 Fast Ethernet Card
Upgrade GPU
This category provides verified compatible upgrade paths. ICD engineers validate every part for compatibility with your specific server model and workload requirements.
227933-B21 HP Ssl Accelerator Card
350732U00-245-G HPE DL380 DL385 DL580 GEN10 GPU 6PX6P Y-power Cable
404563 HPE Ati Fire Gl Video Card
413106 HPE 412831 001 Ati Firegl V3300 128MB Graphics Card
413110 HPE NVIDIA Quadro FX3500 256MB Graphics
452372 HPE Sps Brd 4X PCIe Dual Port Hca
Upgrade Controllers
Upgrading your RAID controller enables faster disk I/O, larger cache, and support for newer drive technologies. Essential when adding NVMe or SAS-4 drives.
218382-001 HP HOT-PLUG Redundant Fan
300874-B21 HP 2-GB DP FC Mezzanine Card
305313-001 HP 2-GB DP FC Mezzanine Card
305442 HPE DL360 G3 PCI Riser Assembly
322595 HPE Fibre Channel I O Module B Board
359248 HPE PCI X Riser Cage for DL380 G4
Upgrade Processors
CPU upgrades deliver more cores and higher clock speeds. If your workload is CPU-bound (compilation, analytics, HPC), upgrading from 8-core to 16+ core processors provides significant throughput improvement.
409598 HPE B21 Intel Xeon X5063 3 2GHZ 4MB Dual Core Processor Kit for BL460C
418323-B21 HP 5150 2.66GHZ DL380 G5
433098-B21 HP E5320 1.86GHZ ML370 G5
433104-B21 HP X5355 2.66GHZ ML370 G5
435513-B21 HP E5310 1.60GHZ ML350 G5
435564 HPE B21 Quad Core Intel Xeon E5345 2 33GHZ 8MB Processor Kit for BL460C
More ProLiant DL380p Gen8 Resources
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