HPE ProLiant DL345 Gen11 Upgrade Guide
Maximize the performance and lifespan of your ProLiant DL345 Gen11 (Gen11). Every upgrade option below is verified compatible.
Verified Specifications
| Processor Options | Single 4th/5th Gen AMD EPYC (up to 160 cores, 400W) - 2U 1P storage-optimized |
| Memory Configuration | Up to 3 TB DDR5 |
| Drive Configurations | Up to 20x LFF / 34x SFF / 36x EDSFF - PCIe Gen5 |
| GPU Options | Up to 4x GPUs (front) |
| Specification Source | HPE official documentation (verified 2026-07-02) |
Frequently Asked Questions
Upgrade Storage
Moving from spinning disk to SSD or NVMe storage provides the largest single performance improvement — often 10-50x faster I/O. Consider NVMe for boot drives and high-IOPS workloads.
375696-001 HPE 36GB 10K SAS SFF SP HDD
375696-002 HP 72-GB 3G 10K 2.5 SP SAS HDD
375712-001 HPE 36GB 10K SAS SFF SP HDD
375859 HPE B21 375863 001 36GB 10K 3GB SAS SFF Hard Drive
375859-B21 HPE 36GB 10K SAS SFF SP HDD
375859R-B21 HP 36GB 10K SAS Hot Plug 2.5IN Hard Drive Disk (HDD)
Upgrade Networking
Stepping up from 1GbE to 10GbE or 25GbE eliminates network bottlenecks for VM migration, iSCSI storage traffic, and backup windows. Most modern workloads benefit from at least 10GbE.
118042-001 HP PCI10 100 NIC Card
127552-B21 HP 8-PORT Fiber Channel Switch
127553-B21 HP 16-PORT Fibre Channel Switch
138603-B21 HP NC3134 NIC 64 PCI Dual Port 10/100
161105-001 HP NC3134 Dual NIC Card
161106-001 HP NC3135 Fast Ethernet Card
Upgrade Power & Cooling
This category provides verified compatible upgrade paths. ICD engineers validate every part for compatibility with your specific server model and workload requirements.
0957 HPE 2320 Redundant Power Supply for RX3600 RX6600
0HPX07 Dell Pe 495W Power Supply
122225-001 HP ML530 Redundant Fan Kit
122633-001 Fan: Fan - Chassis Fan 120MM 130CFM V/Speed 3BL
123482 HPE Storageworks Fan Module for M5314
123482-005 HP Fan Assembly
Upgrade Controllers
Upgrading your RAID controller enables faster disk I/O, larger cache, and support for newer drive technologies. Essential when adding NVMe or SAS-4 drives.
001 HP 4M Netraid Adapter 128MB
158223-B21 HP 16-PORT Fibre Channel Switch
176804-002 HP 1-GB 64-BIT PCI Fibre Channel
218382-001 HP HOT-PLUG Redundant Fan
250176-001 HP Fiber Channel Host
261329-B21 HP 2-GB 64-BIT PCI - FC
Upgrade GPU
This category provides verified compatible upgrade paths. ICD engineers validate every part for compatibility with your specific server model and workload requirements.
227933-B21 HP Ssl Accelerator Card
350732U00-245-G HPE DL380 DL385 DL580 GEN10 GPU 6PX6P Y-power Cable
404563 HPE Ati Fire Gl Video Card
413106 HPE 412831 001 Ati Firegl V3300 128MB Graphics Card
413110 HPE NVIDIA Quadro FX3500 256MB Graphics
452372 HPE Sps Brd 4X PCIe Dual Port Hca
Upgrade Memory
Memory is the most impactful upgrade for virtualization and database workloads. Upgrading from 64GB to 128GB or 256GB can dramatically improve VM density and application response times.
590489-B21 HP CPU Memory Upgrade
P43322-B21 HPE 16GB 1Rx8 RDIMM DDR5-4800 PC5-38400R ECC Memory
P43322-K21 HPE 16GB RDIMM DDR5-4800 PC5-38400R ECC Memory
P43324-0A1 HPE 16GB RDIMM DDR5-4800 PC5-38400R ECC Memory
P43324-1A1 HPE 16GB RDIMM DDR5-4800 PC5-38400R ECC Memory
P43325-B21 HPE 32GB RDIMM DDR5-4800 PC5-38400R ECC Memory
Upgrade Processors
CPU upgrades deliver more cores and higher clock speeds. If your workload is CPU-bound (compilation, analytics, HPC), upgrading from 8-core to 16+ core processors provides significant throughput improvement.
001 HP 4M Netraid Adapter 128MB
066WT AMD Epyc™ 7453 2.75GHZ G10+
120672-B21 Genuine HP
120673-B21 HP ProLiant Server Option Kit
123482-005 HP Fan Assembly
123958-001 HP ProLiant Server Component
More ProLiant DL345 Gen11 Resources
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